Croscarmellose Sodium Superdisintegrant ya Mapiritsi a Mankhwala | Kutupa Mwachangu, Kugwiritsa Ntchito Kochepa 0.5-5% | USP/EP/JP Yogwirizana

Croscarmellose Sodium yathu ndi superdisintegrant yoyera kwambiri yopangidwira kumwa mapiritsi olimba kuphatikiza mapiritsi, makapisozi, ndi granules. Ndi sodium carboxymethylcellulose yolumikizidwa mkati yomwe sisungunuka m'madzi koma imakula mofulumira mpaka kuwirikiza ka 4-8 kuchuluka kwake koyambirira ikakhudzana ndi madzi.Kapangidwe kake kapadera ka ulusi kamapereka mphamvu yabwino kwambiri yothira madzi ndi ntchito ya capillary, zomwe zimapangitsa kuti mapiritsi azisweka bwino komanso kuti mankhwala azisungunuka bwino.Zimagwirizana ndi mankhwala a USP-NF, EP, JP, ndi ChP okhala ndi CDE registration F20209990136Mlingo wogwiritsidwa ntchito nthawi zambiri: 0.5-5.0% w/w (2% ya kukanikiza mwachindunji, 3% ya kunyowa kwa granulation)Yoyenera kugwiritsidwa ntchito popondereza mwachindunji, popondereza zinthu monyowa (mkati kapena kunja kwa granular), popondereza zinthu zozungulira, komanso popondereza zinthu zozungulira.

Lumikizanani nafe

Tsatanetsatane wa Zamalonda

Mankhwala a mtundu wa Croscarmellose Sodium (CCS)

Chidule cha Zamalonda

Croscarmellose Sodium ndi sodium carboxymethylcellulose yolumikizidwa mkati, yopangidwa makamaka kuti igwiritsidwe ntchito ngati superdisintegrant mu mankhwala opangira mankhwala.Mosiyana ndi zinthu zongowola zomwe zimagwiritsidwa ntchito nthawi zonse, zimapereka mphamvu zabwino kwambiri zongowola pamlingo wochepa, kuonetsetsa kuti mapiritsi amawonongeka mwachangu komanso kusungunuka bwino kwa mankhwala kuti azitha kupezeka mosavuta..

Chidziwitso cha Zamalonda:

Dzina la Mankhwala:Sodium ya Croscarmellose
Nambala ya CAS:74811-65-7
Nambala Yolembetsa ya CDE:F20209990136
Kutsatira Malamulo a Pharmacopoeia:ChP, USP-NF, EP, JP, BP
Nambala ya EC:629-739-2
Mawu ofanana:Carboxymethylcellulose yolumikizidwa ndi Cross-linked Sodium, CCNa, Sodium Croscarmellose, E468

Zinthu Zofunika & Mapindu

1. Njira Yapamwamba Yogawikana

Kugawanika kwa zochita ziwiri:Zimaphatikiza ntchito ya capillary (kupukuta) ndi kutupa mwachangu
Amapita kuKuchulukitsa voliyumu yake yoyambirira nthawi 4-8ikakhudzana ndi madzi
Kapangidwe ka ulusi kamapereka mphamvu zabwino kwambiri zoyamwitsa madzi
Amapanga kukula kwa makina komwe kumaphwanya mapiritsi mwachangu

2. Kugwiritsa Ntchito Mochepa - Kugwiritsa Ntchito Moyenera Kwambiri

Yogwira ntchito bwino pamlingo wochepa ngati0.5-5.0% w/w
Kagwiritsidwe ntchito wamba: 2% pa kukanikiza mwachindunji, 3% pa kunyowa kwa granulation
Yankho lotsika mtengo pakupanga mapangidwe

3. Kusinthasintha kwa Kupanga

Yoyenera njira zonse zopangira mapiritsi: kukanikiza mwachindunji, kunyowa kwa granulation, kukanikiza kwa roller
Mu granulation yonyowa, ingagwiritsidwe ntchito mkati mwa granulally, extra-granulally, kapena kugawidwa pakati pa magawo onse awiri
Imagwirizana ndi ma kapisozi (10-25% yogwiritsidwa ntchito)

4. Katundu Wabwino Kwambiri

Maonekedwe:Ufa wochokera woyera mpaka wochepa, woyenda momasuka
Mlingo wa Kusintha:0.60 – 0.85
Kukhazikitsa Voliyumu:10.0 – 30.0 ml
pH (1% yankho):5.0 – 7.0
Kutayika pa Kuumitsa:≤10.0%
Zotsalira pa Kuyatsa:14.0% – 28.0%
Zinthu Zosungunuka ndi Madzi:≤10.0%
Zitsulo Zolemera:≤10 ppm

5. Kugwirizana ndi Kukhazikika kwa API

Kodimulibe peroxides- zimatsimikizira kukhazikika bwino kwa ma API omwe ali ndi vuto la okosijeni
Palibe zotsatira zoyipa pa kuuma kwa piritsi kapena kufooka kwake
Kusweka kwa ntchito kumakhalabe kofanana pakapita nthawi
Sizimayambitsa matenda a GMO, sizimayambitsa ziwengo