Carboxymethylcellulose Calcium (CMC-Ca) Superdisintegrant | Kutupa Kwambiri kwa Mapiritsi Osweka Mwamsanga | USP/EP/ChP Compliant

Carboxymethylcellulose Calcium (Carmellose Calcium, CMC-Ca) ndi mankhwala oyeretsera omwe amagwira ntchito ngati chosakaniza, chomangira, komanso chosungunula bwino pakamwa.Ndi mchere wa calcium wa carboxymethylcellulose, womwe umawoneka ngati ufa woyera mpaka woyera womwe sungasungunuke m'madzi koma umakula mofulumira kuwirikiza kangapo kuchuluka kwake koyambirira ukakhudzana ndi madzi.Njira yapadera yotupa iyi imatsimikizira kuti mapiritsi amasungunuka mwachangu komanso kuti mankhwalawo asungunuke bwino. Ubwino waukulu ndi monga: kusowa kwa sodium (koyenera odwala omwe ali ndi matenda a mtima ndi mtima komanso omwe ali ndi sodium yochepa)., kupanikizika kwabwino kwambiri, komanso kugwirizana ndi njira zonse ziwiri zopondereza mwachindunji komanso zonyowa . Zimagwirizana ndi USP-NF, EP, JP, ndi ChP pharmacopoeias yokhala ndi CDE registration F20230000328. Mlingo wogwiritsidwa ntchito wamba: 0.5-15% w/w.

Lumikizanani nafe

Tsatanetsatane wa Zamalonda

Mankhwala Opangira Carboxymethylcellulose Calcium (Carmellose Calcium, CMC-Ca)

Chidule cha Zamalonda

Carboxymethylcellulose Calcium ndi mchere wa calcium wa polycarboxymethyl ether ya celluloseNdi mankhwala ophatikizika omwe amagwiritsidwa ntchito kwambiri ngati mankhwala ophatikizika, omangira, komanso osungunula m'njira zolimba zomwa kuphatikiza mapiritsi ndi makapisozi.Mosiyana ndi sodium, mchere wa calcium umapereka ubwino wokhala ndi sodium, zomwe zimapangitsa kuti ukhale woyenera kwambiri kwa odwala matenda a mtima ndi mtima omwe ali ndi vuto la sodium yochepa..

Chidziwitso cha Zamalonda:

Dzina la Mankhwala:Carboxymethylcellulose Calcium / Carmelose Calcium
Nambala ya CAS:9050-04-8
Nambala Yolembetsa ya CDE:F20230000328
Kutsatira Malamulo a Pharmacopoeia:ChP, USP-NF, EP, JP
Mawu ofanana:Calcium carboxymethylcellulose, Calcium CMC, CMC-Ca, Carmelose Calcium
ENA:UTY7PDF93L
Maonekedwe:Ufa woyera mpaka wachikasu kapena woyera pang'ono, wowoneka bwino ukauma
Kusungunuka:Sisungunuka m'madzi, acetone, mowa, ndi toluene; imatupa m'madzi kuti ipange suspension

Zinthu Zofunika & Mapindu

1. Njira Yapamwamba Yogawikana

Madzi sasungunuka koma amakula mofulumira mpakakangapo voliyumu yake yoyambiriraatakumana ndi madzi
Amapanga mphamvu yamakina yomwe imaphwanya mapiritsi mwachangu
Zimathandiza kuti mankhwala asungunuke mwachangu komanso mokwanira kuti athetsedwe mosavuta
Imagwira ntchito bwino ngakhale m'mapiritsi olimba pomwe zinthu zina zosungunuka sizingagwire ntchito mokwanira

2. Chowonjezera Chogwira Ntchito Zambiri

Wosasinthika:Ntchito yayikulu ngati piritsi losagwira ntchito bwino pamlingo wa 0.5-15%.
Chomangira:Chomangira chogwira ntchito bwino mu njira zonyowa za granulation
Chosungunula/Chodzaza:Itha kugwiritsidwa ntchito ngati mankhwala ochepetsa ululu
Chithandizo Choyimitsa:Amagwiritsidwa ntchito ngati chokhazikika cha suspension mu zokonzekera za pakamwa ndi zakunja

3. Ubwino Wopanda Sodium

Mulibe sodium - yabwino kwa odwala omwe ali ndi vuto la mtima komanso omwe ali ndi vuto la sodium yochepa
Amathetsa kufunikira kwa malamulo ndi odwala kwa mankhwala otsika sodium
Imakwaniritsa njira zodziwika bwino komanso zoganizira zaumoyo

4. Kugwirizana Kwabwino Kwambiri ndi API

Zothandiza kwambiri pamankhwala a cephalosporin, yokhala ndi makhalidwe owonetsera okonzanso kusungunuka
Kapangidwe kabwino ka chelating kamapindulitsa magulu ena a API
Imagwirizana ndi zosakaniza zosiyanasiyana zogwira ntchito monga: Pioglitazone HCl, Aminophylline, Berberine HCl, Milnacipran HCl, Cefixime, Nicorandil, ndi zina zambiri.

5. Katundu Wapamwamba Kwambiri